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• Motoyama, K
• Higashi, T
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• Motoyama, K
• Higashi, T
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• Motoyama, K
• Higashi, T

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Pharmaceutics 2012, 4(1), 130-148; doi:10.3390/pharmaceutics4010130

Review

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA

Hidetoshi Arima* , Keiichi Motoyama and Taishi Higashi

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan

* Author to whom correspondence should be addressed.

Received: 4 January 2012; in revised form: 20 January 2012 / Accepted: 20 January 2012 / Published: 1 February 2012

(This article belongs to the Special Issue Gene Therapy)

Download PDF Full-Text [1131 KB, uploaded 1 February 2012 14:08 CET]

Abstract: Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) Starburst^TM dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recently, multifunctional PAMAM dendrimers can be used for the wide range of biomedical applications including intracellular delivery of genes and nucleic acid drugs. In this context, this review paper provides the recent findings on PAMAM dendrimer conjugates with cyclodextrins (CyDs) for gene, shRNA and siRNA delivery.

Keywords: cyclodextrin; polyamidoamine dendrimer; conjugate; DNA delivery; shRNA delivery; siRNA delivery

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