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Pharmaceutics 2012, 4(1), 130-148; doi:10.3390/pharmaceutics4010130
Review

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA

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Received: 4 January 2012 / Revised: 20 January 2012 / Accepted: 20 January 2012 / Published: 1 February 2012
(This article belongs to the Special Issue Gene Therapy)
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Abstract

Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) StarburstTM dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recently, multifunctional PAMAM dendrimers can be used for the wide range of biomedical applications including intracellular delivery of genes and nucleic acid drugs. In this context, this review paper provides the recent findings on PAMAM dendrimer conjugates with cyclodextrins (CyDs) for gene, shRNA and siRNA delivery.
Keywords: cyclodextrin; polyamidoamine dendrimer; conjugate; DNA delivery; shRNA delivery; siRNA delivery cyclodextrin; polyamidoamine dendrimer; conjugate; DNA delivery; shRNA delivery; siRNA delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Arima, H.; Motoyama, K.; Higashi, T. Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA. Pharmaceutics 2012, 4, 130-148.

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