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• AlHusban, F
• ElShaer, AM.
• Kansara, JH.
• Smith, AM.
• Grover, LM.
• Perrie, Y
• Mohammed, AR.
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• AlHusban, F
• ElShaer, AM.
• Kansara, JH.
• Smith, AM.
• Grover, LM.
• Perrie, Y
• Mohammed, AR.
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• AlHusban, F
• ElShaer, AM.
• Kansara, JH.
• Smith, AM.
• Grover, LM.
• Perrie, Y
• Mohammed, AR.

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Pharmaceutics 2010, 2(1), 1-17; doi:10.3390/pharmaceutics2010001

Article

Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination

Farhan AlHusban ^1,† , Amr M. ElShaer ^1,† , Jiteen H. Kansara ¹ , Alan M. Smith ² , Liam M. Grover ² , Yvonne Perrie ¹  and Afzal R. Mohammed ^1,*

¹ Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK ² School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK ^† Both authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 26 November 2009; in revised form: 15 December 2009 / Accepted: 30 December 2009 / Published: 4 January 2010

(This article belongs to the Special Issue What's on Board in Pharmaceutics)

Download PDF Full-Text [159 KB, uploaded 4 January 2010 15:20 CET]

Abstract: Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.

Keywords: orally disintegrating tablets; proline; serine; lyophilisation; annealing; sublimation rate

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