Pharmaceutics 2010, 2(1), 1-17; doi:10.3390/pharmaceutics2010001
Article

Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination

1 Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK 2 School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Both authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 November 2009; in revised form: 15 December 2009 / Accepted: 30 December 2009 / Published: 4 January 2010
(This article belongs to the Special Issue What's on Board in Pharmaceutics)
PDF Full-text Download PDF Full-Text [159 KB, uploaded 4 January 2010 15:20 CET]
Abstract: Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.
Keywords: orally disintegrating tablets; proline; serine; lyophilisation; annealing; sublimation rate

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

AlHusban, F.; ElShaer, A.M.; Kansara, J.H.; Smith, A.M.; Grover, L.M.; Perrie, Y.; Mohammed, A.R. Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics 2010, 2, 1-17.

AMA Style

AlHusban F, ElShaer AM, Kansara JH, Smith AM, Grover LM, Perrie Y, Mohammed AR. Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics. 2010; 2(1):1-17.

Chicago/Turabian Style

AlHusban, Farhan; ElShaer, Amr M.; Kansara, Jiteen H.; Smith, Alan M.; Grover, Liam M.; Perrie, Yvonne; Mohammed, Afzal R. 2010. "Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination." Pharmaceutics 2, no. 1: 1-17.

Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert