Pharmaceutics 2009, 1(1), 3-19; doi:10.3390/pharmaceutics1010003

Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems

1 Department SMETEC, University of Bologna, Via San Donato, 15, 40127 Bologna, Italy 2 Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro, 6, 40126 Bologna, Italy 3 Department of Physical and Inorganic Chemistry, University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy
* Author to whom correspondence should be addressed.
Received: 6 August 2009; in revised form: 3 October 2009 / Accepted: 6 October 2009 / Published: 9 October 2009
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Abstract: Six mixtures, containing 10, 20 and 30% w/w ibuprofen and isomalt, were compacted by a traditional or ultrasound-assisted machine and analysed by means of thermal (DSC and TGA) and micro-spectrometry (Raman and FT-IR) techniques. Ultrasound discharge causes melting of ibuprofen powder, transforming into a paste that could not assume the shape of a tablet; when in mixture with isomalt, thermal events, occurring during ultrasound compaction, change the appearance of the particles formed by milling the tablets obtained this way and SEM photos reveal a dramatic reduction of the particle size and changes due to a possible ibuprofen re-crystallization. Raman and FT-IR spectra of small portions of the surface and of the bulk, using characteristic peaks for identification, reveal that in ultrasound-compacted tablets ibuprofen partially disappears from the top face of the tablet.
Keywords: ibuprofen; isomalt; traditional and ultrasound compaction; thermal analysis; SEM; Raman and FT-IR spectra

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MDPI and ACS Style

Fini, A.; Cavallari, C.; Ospitali, F. Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems. Pharmaceutics 2009, 1, 3-19.

AMA Style

Fini A, Cavallari C, Ospitali F. Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems. Pharmaceutics. 2009; 1(1):3-19.

Chicago/Turabian Style

Fini, Adamo; Cavallari, Cristina; Ospitali, Francesca. 2009. "Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems." Pharmaceutics 1, no. 1: 3-19.

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