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Pharmaceutics: A New Open-Access Journal for All Those Interested in Designing Medicines
Pharmaceutics 2009, 1(1), 3-19; doi:10.3390/pharmaceutics1010003
Article

Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems

1,* , 2 and 3
Received: 6 August 2009; in revised form: 3 October 2009 / Accepted: 6 October 2009 / Published: 9 October 2009
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Abstract: Six mixtures, containing 10, 20 and 30% w/w ibuprofen and isomalt, were compacted by a traditional or ultrasound-assisted machine and analysed by means of thermal (DSC and TGA) and micro-spectrometry (Raman and FT-IR) techniques. Ultrasound discharge causes melting of ibuprofen powder, transforming into a paste that could not assume the shape of a tablet; when in mixture with isomalt, thermal events, occurring during ultrasound compaction, change the appearance of the particles formed by milling the tablets obtained this way and SEM photos reveal a dramatic reduction of the particle size and changes due to a possible ibuprofen re-crystallization. Raman and FT-IR spectra of small portions of the surface and of the bulk, using characteristic peaks for identification, reveal that in ultrasound-compacted tablets ibuprofen partially disappears from the top face of the tablet.
Keywords: ibuprofen; isomalt; traditional and ultrasound compaction; thermal analysis; SEM; Raman and FT-IR spectra ibuprofen; isomalt; traditional and ultrasound compaction; thermal analysis; SEM; Raman and FT-IR spectra
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fini, A.; Cavallari, C.; Ospitali, F. Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems. Pharmaceutics 2009, 1, 3-19.

AMA Style

Fini A, Cavallari C, Ospitali F. Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems. Pharmaceutics. 2009; 1(1):3-19.

Chicago/Turabian Style

Fini, Adamo; Cavallari, Cristina; Ospitali, Francesca. 2009. "Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems." Pharmaceutics 1, no. 1: 3-19.


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