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Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems
Department SMETEC, University of Bologna, Via San Donato, 15, 40127 Bologna, Italy
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro, 6, 40126 Bologna, Italy
Department of Physical and Inorganic Chemistry, University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy
* Author to whom correspondence should be addressed.
Received: 6 August 2009; in revised form: 3 October 2009 / Accepted: 6 October 2009 / Published: 9 October 2009
Abstract: Six mixtures, containing 10, 20 and 30% w/w ibuprofen and isomalt, were compacted by a traditional or ultrasound-assisted machine and analysed by means of thermal (DSC and TGA) and micro-spectrometry (Raman and FT-IR) techniques. Ultrasound discharge causes melting of ibuprofen powder, transforming into a paste that could not assume the shape of a tablet; when in mixture with isomalt, thermal events, occurring during ultrasound compaction, change the appearance of the particles formed by milling the tablets obtained this way and SEM photos reveal a dramatic reduction of the particle size and changes due to a possible ibuprofen re-crystallization. Raman and FT-IR spectra of small portions of the surface and of the bulk, using characteristic peaks for identification, reveal that in ultrasound-compacted tablets ibuprofen partially disappears from the top face of the tablet.
Keywords: ibuprofen; isomalt; traditional and ultrasound compaction; thermal analysis; SEM; Raman and FT-IR spectra
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Fini, A.; Cavallari, C.; Ospitali, F. Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems. Pharmaceutics 2009, 1, 3-19.
Fini A, Cavallari C, Ospitali F. Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems. Pharmaceutics. 2009; 1(1):3-19.
Fini, Adamo; Cavallari, Cristina; Ospitali, Francesca. 2009. "Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems." Pharmaceutics 1, no. 1: 3-19.