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Pharmaceutics 2018, 10(2), 59; https://doi.org/10.3390/pharmaceutics10020059

Pre-Clinical and Clinical Efficiency of Complexes of Oligoribonucleotides with D-Mannitol against Respiratory Viruses

1
Institute of Molecular Biology and Genetics, National Academy Science of Ukraine, 03680 Kyiv, Ukraine
2
Pasteur Institute of Epidemiology and Microbiology, 14 Mira str, 197101 St. Petersburg, Russia
3
Department of Infectious Diseases and Epidemiology, I. Ya. Horbachevsky Ternopil State Medical University, 46002 Ternopil, Ukraine
*
Author to whom correspondence should be addressed.
Received: 12 March 2018 / Revised: 30 April 2018 / Accepted: 14 May 2018 / Published: 19 May 2018
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Abstract

Oligoribonucleotides-D-mannitol (ORNs-D-M) complexes possess antiviral, anti-inflammatory, and immunomodulatory actions. The aim of the present study was to evaluated an antiviral effect of ORNs-D-M against parainfluenza virus type 3 (PIV3); influenza CA709, PR834; avian influenza virus H5N2 (AIV) in vitro by a TCID50; hemadsorption and neuraminidase activity assays; and clinical efficiency of ORNs-D-M in patients with acute respiratory infections (ARIs) of various etiologies by PCR assay and AmpliSens test systems. It was observed that ORNs-D-M have an antiviral activity against the influenza CA709, PR834, PIV3, and AIV in vitro. The injectable dosage form of ORNs-D-M was shown to have a stronger antiviral effect compared to capsule form. It was also detected that the injectable form of ORNs-D-M significantly reduced the neuraminidase activity of influenza PR834. A complex treatment of patients with ORNs-D-M had a positive effect on the course of the disease, it accelerated patients’ recovery. Treatment with ORNs-D-M caused eradication of adeno- and influenza viruses in patients with ARI. This drug contributed to significant decrease in duration of febrile period and cough. Comprehensive treatment with ORNs-D-M improved the disease clinical findings significantly. Collectively, these results suggested that ORNs-D-M may be used at co-infection with influenza and other respiratory viruses as a medical antiviral drug. View Full-Text
Keywords: acute respiratory infections; oligoribonucleotides-D-mannitol complexes acute respiratory infections; oligoribonucleotides-D-mannitol complexes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Melnichuk, N.; Zarubaev, V.; Iosyk, I.; Andreychyn, M.; Semernikova, L.; Tkachuk, Z. Pre-Clinical and Clinical Efficiency of Complexes of Oligoribonucleotides with D-Mannitol against Respiratory Viruses. Pharmaceutics 2018, 10, 59.

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