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Pharmaceutics 2018, 10(2), 55; https://doi.org/10.3390/pharmaceutics10020055

Sustained Release Drug Delivery Applications of Polyurethanes

1
College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA
2
MRL, Merck & Co., Inc., 126 E. Lincoln Ave, Rahway, NJ 07065, USA
*
Authors to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 2 May 2018 / Accepted: 4 May 2018 / Published: 9 May 2018
(This article belongs to the Special Issue Pharmaceutical Applications of Hot-melt Extrusion)
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Abstract

Since their introduction over 50 years ago, polyurethanes have been applied to nearly every industry. This review describes applications of polyurethanes to the development of modified release drug delivery. Although drug delivery research leveraging polyurethanes has been ongoing for decades, there has been renewed and substantial interest in the field in recent years. The chemistry of polyurethanes and the mechanisms of drug release from sustained release dosage forms are briefly reviewed. Studies to assess the impact of intrinsic drug properties on release from polyurethane-based formulations are considered. The impact of hydrophilic water swelling polyurethanes on drug diffusivity and release rate is discussed. The role of pore formers in modulating drug release rate is examined. Finally, the value of assessing mechanical properties of the dosage form and approaches taken in the literature are described. View Full-Text
Keywords: polyurethane; isocyanate; long-acting; sustained release; drug delivery polyurethane; isocyanate; long-acting; sustained release; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lowinger, M.B.; Barrett, S.E.; Zhang, F.; Williams, R.O., III. Sustained Release Drug Delivery Applications of Polyurethanes. Pharmaceutics 2018, 10, 55.

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