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Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
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Pharmaceutics 2018, 10(1), 18; https://doi.org/10.3390/pharmaceutics10010018

Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs

1
Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54351 Thessaloniki, Greece
2
Faculty of Engineering and Science, University of Greenwich at Medway, Kent ME4 4TB, UK
*
Author to whom correspondence should be addressed.
Received: 29 November 2017 / Revised: 2 January 2018 / Accepted: 10 January 2018 / Published: 25 January 2018
(This article belongs to the Special Issue Pharmaceutical Crystallisation Science and Engineering)
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Abstract

Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmaceutical interest, along with their in vitro properties and available in vivo data and characterization techniques are discussed, highlighting the potential of cocrystals as an attractive route for drug development. View Full-Text
Keywords: cocrystals; coformers; solid state properties; poorly soluble APIs cocrystals; coformers; solid state properties; poorly soluble APIs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Karagianni, A.; Malamatari, M.; Kachrimanis, K. Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs. Pharmaceutics 2018, 10, 18.

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