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Viruses 2017, 9(8), 230; doi:10.3390/v9080230

Interference of Apoptosis by Hepatitis B Virus

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
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Author to whom correspondence should be addressed.
Academic Editor: Marc Kvansakul
Received: 30 June 2017 / Revised: 7 August 2017 / Accepted: 10 August 2017 / Published: 18 August 2017
(This article belongs to the Special Issue Viral Infection and Apoptosis)
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Abstract

Hepatitis B virus (HBV) causes liver diseases that have been a consistent problem for human health, leading to more than one million deaths every year worldwide. A large proportion of hepatocellular carcinoma (HCC) cases across the world are closely associated with chronic HBV infection. Apoptosis is a programmed cell death and is frequently altered in cancer development. HBV infection interferes with the apoptosis signaling to promote HCC progression and viral proliferation. The HBV-mediated alteration of apoptosis is achieved via interference with cellular signaling pathways and regulation of epigenetics. HBV X protein (HBX) plays a major role in the interference of apoptosis. There are conflicting reports on the HBV interference of apoptosis with the majority showing inhibition of and the rest reporting induction of apoptosis. In this review, we described recent studies on the mechanisms of the HBV interference with the apoptosis signaling during the virus infection and provided perspective. View Full-Text
Keywords: hepatitis B virus (HBV); apoptosis; hepatocellular carcinoma (HCC); X protein hepatitis B virus (HBV); apoptosis; hepatocellular carcinoma (HCC); X protein
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Lin, S.; Zhang, Y.-J. Interference of Apoptosis by Hepatitis B Virus. Viruses 2017, 9, 230.

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