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Viruses 2017, 9(7), 159; doi:10.3390/v9070159

Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA
Current address: Department of Entomology, Kansas State University, Manhattan, KS 66506, USA
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Author to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Received: 26 April 2017 / Revised: 19 June 2017 / Accepted: 20 June 2017 / Published: 23 June 2017
(This article belongs to the Section Antivirals & Vaccines)
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Abstract

Dengue virus (DENV) is a mosquito-borne flavivirus that causes significant global human disease and mortality. One approach to develop treatments for DENV infection and the prevention of severe disease is through investigation of natural medicines. Inflammation plays both beneficial and harmful roles during DENV infection. Studies have proposed that the oxidative stress response may be one mechanism responsible for triggering inflammation during DENV infection. Thus, blocking the oxidative stress response could reduce inflammation and the development of severe disease. Garlic has been shown to both reduce inflammation and affect the oxidative stress response. Here, we show that the garlic active compounds diallyl disulfide (DADS), diallyl sulfide (DAS) and alliin reduced inflammation during DENV infection and show that this reduction is due to the effects on the oxidative stress response. These results suggest that garlic could be used as an alternative treatment for DENV infection and for the prevention of severe disease development. View Full-Text
Keywords: dengue virus; inflammation; oxidative stress response; alternative medicine dengue virus; inflammation; oxidative stress response; alternative medicine
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MDPI and ACS Style

Hall, A.; Troupin, A.; Londono-Renteria, B.; Colpitts, T.M. Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection. Viruses 2017, 9, 159.

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