Bacterial Virus Ontology; Coordinating across Databases
AbstractBacterial viruses, also called bacteriophages, display a great genetic diversity and utilize unique processes for infecting and reproducing within a host cell. All these processes were investigated and indexed in the ViralZone knowledge base. To facilitate standardizing data, a simple ontology of viral life-cycle terms was developed to provide a common vocabulary for annotating data sets. New terminology was developed to address unique viral replication cycle processes, and existing terminology was modified and adapted. Classically, the viral life-cycle is described by schematic pictures. Using this ontology, it can be represented by a combination of successive events: entry, latency, transcription/replication, host–virus interactions and virus release. Each of these parts is broken down into discrete steps. For example enterobacteria phage lambda entry is broken down in: viral attachment to host adhesion receptor, viral attachment to host entry receptor, viral genome ejection and viral genome circularization. To demonstrate the utility of a standard ontology for virus biology, this work was completed by annotating virus data in the ViralZone, UniProtKB and Gene Ontology databases. View Full-Text
Share & Cite This Article
Hulo, C.; Masson, P.; Toussaint, A.; Osumi-Sutherland, D.; de Castro, E.; Auchincloss, A.H.; Poux, S.; Bougueleret, L.; Xenarios, I.; Le Mercier, P. Bacterial Virus Ontology; Coordinating across Databases. Viruses 2017, 9, 126.
Hulo C, Masson P, Toussaint A, Osumi-Sutherland D, de Castro E, Auchincloss AH, Poux S, Bougueleret L, Xenarios I, Le Mercier P. Bacterial Virus Ontology; Coordinating across Databases. Viruses. 2017; 9(6):126.Chicago/Turabian Style
Hulo, Chantal; Masson, Patrick; Toussaint, Ariane; Osumi-Sutherland, David; de Castro, Edouard; Auchincloss, Andrea H.; Poux, Sylvain; Bougueleret, Lydie; Xenarios, Ioannis; Le Mercier, Philippe. 2017. "Bacterial Virus Ontology; Coordinating across Databases." Viruses 9, no. 6: 126.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.