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Viruses 2017, 9(4), 77; doi:10.3390/v9040077

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

Center for Vaccine Research, Departments of Microbiology and Molecular Genetics, and Immunology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
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Author to whom correspondence should be addressed.
Academic Editor: Michael R. Holbrook
Received: 6 March 2017 / Revised: 4 April 2017 / Accepted: 6 April 2017 / Published: 11 April 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
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Abstract

The 17D line of yellow fever virus vaccines is among the most effective vaccines ever created. The humoral and cellular immunity elicited by 17D has been well characterized in humans. Neutralizing antibodies have long been known to provide protection against challenge with a wild-type virus. However, a well characterized T cell immune response that is robust, long-lived and polyfunctional is also elicited by 17D. It remains unclear whether this arm of immunity is protective following challenge with a wild-type virus. Here we introduce the 17D line of yellow fever virus vaccines, describe the current state of knowledge regarding the immunity directed towards the vaccines in humans and conclude with a discussion of animal models that are useful for evaluating T cell-mediated immune protection to yellow fever virus. View Full-Text
Keywords: yellow fever virus; YFV; flavivirus; 17D; 17DD; 17D-204; T cell; vaccine; animal models; dengue; West Nile; Zika; live attenuated vaccine; chimerivax; vaccine development yellow fever virus; YFV; flavivirus; 17D; 17DD; 17D-204; T cell; vaccine; animal models; dengue; West Nile; Zika; live attenuated vaccine; chimerivax; vaccine development
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Watson, A.M.; Klimstra, W.B. T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models. Viruses 2017, 9, 77.

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