Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6
AbstractHepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently. It was recently shown that transcription from the HBV genome (covalently-closed circular DNA, cccDNA) is inhibited by the structural maintenance of chromosome 5/6 complex (Smc5/6), and that a key function of HBx is to redirect the DNA-damage binding protein 1 (DDB1) E3 ubiquitin ligase to target this complex for degradation. By doing so, HBx alleviates transcriptional repression by Smc5/6 and stimulates HBV gene expression. In this review, we discuss in detail how the interplay between HBx and Smc5/6 was identified and characterized. We also discuss what is known regarding the repression of cccDNA transcription by Smc5/6, the timing of HBx expression, and the potential role of HBx in promoting hepatocellular carcinoma (HCC). View Full-Text
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Livingston, C.M.; Ramakrishnan, D.; Strubin, M.; Fletcher, S.P.; Beran, R.K. Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6. Viruses 2017, 9, 69.
Livingston CM, Ramakrishnan D, Strubin M, Fletcher SP, Beran RK. Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6. Viruses. 2017; 9(4):69.Chicago/Turabian Style
Livingston, Christine M.; Ramakrishnan, Dhivya; Strubin, Michel; Fletcher, Simon P.; Beran, Rudolf K. 2017. "Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6." Viruses 9, no. 4: 69.
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