AbstractPreclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which infects the Mastomys species of multimammate rats, and MmuPV1, which infects laboratory mice, are currently the most studied rodent PVs. Both of these viruses cause malignancy in the skin and can provide attractive infection models to study the lesser understood cutaneous papillomaviruses that have been frequently associated with HPV-related skin cancers. Of these, MmuPV1 is the first reported rodent papillomavirus that can naturally infect the laboratory strain of mice. MmuPV1 is an attractive model virus to study papillomavirus pathogenesis because of the ubiquitous availability of lab mice and the fact that this mouse species is genetically modifiable. In this review, we have summarized the knowledge we have gained about PV biology from the study of rodent papillomaviruses and point out the remaining gaps that can provide new research opportunities. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2196 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Uberoi, A.; Lambert, P.F. Rodent Papillomaviruses. Viruses 2017, 9, 362.
Uberoi A, Lambert PF. Rodent Papillomaviruses. Viruses. 2017; 9(12):362.Chicago/Turabian Style
Uberoi, Aayushi; Lambert, Paul F. 2017. "Rodent Papillomaviruses." Viruses 9, no. 12: 362.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.