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Viruses 2017, 9(12), 362; doi:10.3390/v9120362

Rodent Papillomaviruses

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI 53705, USA
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Received: 6 November 2017 / Revised: 20 November 2017 / Accepted: 21 November 2017 / Published: 27 November 2017
(This article belongs to the Section Animal Viruses)
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Abstract

Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which infects the Mastomys species of multimammate rats, and MmuPV1, which infects laboratory mice, are currently the most studied rodent PVs. Both of these viruses cause malignancy in the skin and can provide attractive infection models to study the lesser understood cutaneous papillomaviruses that have been frequently associated with HPV-related skin cancers. Of these, MmuPV1 is the first reported rodent papillomavirus that can naturally infect the laboratory strain of mice. MmuPV1 is an attractive model virus to study papillomavirus pathogenesis because of the ubiquitous availability of lab mice and the fact that this mouse species is genetically modifiable. In this review, we have summarized the knowledge we have gained about PV biology from the study of rodent papillomaviruses and point out the remaining gaps that can provide new research opportunities. View Full-Text
Keywords: papillomaviruses; preclinical models; rodent papillomaviruses; murine papillomavirus papillomaviruses; preclinical models; rodent papillomaviruses; murine papillomavirus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Uberoi, A.; Lambert, P.F. Rodent Papillomaviruses. Viruses 2017, 9, 362.

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