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Viruses 2017, 9(10), 309; https://doi.org/10.3390/v9100309

The Battle of RNA Synthesis: Virus versus Host

1
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
2
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
*
Authors to whom correspondence should be addressed.
Received: 15 September 2017 / Revised: 19 October 2017 / Accepted: 20 October 2017 / Published: 21 October 2017
(This article belongs to the Special Issue Structure-Function Relationships in Viral Polymerases)
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Abstract

Transcription control is the foundation of gene regulation. Whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. Over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. Just as cells are increasingly understood to employ nascent RNAs in transcription regulation, recent discoveries are revealing how viruses use nascent RNAs to benefit their own gene expression. In this review, we first outline the two different transcription programs used by viruses, i.e., transcription (DNA-dependent) and RNA-dependent RNA synthesis. Subsequently, we use the distinct stages (initiation, elongation, termination) to describe the latest insights into nascent RNA-mediated regulation in the context of each relevant stage. View Full-Text
Keywords: transcription; nascent RNA; HIV-1; influenza; Epstein-Barr virus; RNA polymerase II; RNA-dependent RNA polymerase; respiratory syncytial virus transcription; nascent RNA; HIV-1; influenza; Epstein-Barr virus; RNA polymerase II; RNA-dependent RNA polymerase; respiratory syncytial virus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Harwig, A.; Landick, R.; Berkhout, B. The Battle of RNA Synthesis: Virus versus Host. Viruses 2017, 9, 309.

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