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Viruses 2017, 9(10), 308; doi:10.3390/v9100308

Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System

1
Institute for Clinical and Molecular Virology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany
2
Nachwuchsgruppe Herpesviren, Deutsches Primatenzentrum—Leibniz-Institut für Primatenforschung, 37077 Göttingen, Germany
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 18 October 2017 / Accepted: 20 October 2017 / Published: 21 October 2017
(This article belongs to the Special Issue Viruses, ERAD, and the Proteasome)
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Abstract

Gammaherpesviruses like Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. In particular, viral tegument proteins that share sequence homology to the formylglycineamide ribonucleotide amidotransferase (FGARAT, or PFAS), an enzyme in the cellular purine biosynthesis, are important for disrupting the intrinsic antiviral response associated with Promyelocytic Leukemia (PML) protein-associated nuclear bodies (PML-NBs) by proteasome-dependent and independent mechanisms. In addition, all herpesviruses encode for a potent ubiquitin protease that can efficiently remove ubiquitin chains from proteins and thereby interfere with several different cellular pathways. In this review, we discuss mechanisms and functional consequences of virus-induced ubiquitination and deubiquitination for early events in gammaherpesviral infection. View Full-Text
Keywords: Gammaherpesvirus; Epstein-Barr virus; Kaposi’s sarcoma-associated herpesvirus; KSHV; EBV; viral FGARAT; PML nuclear bodies; ubiquitin; proteasome; deubiquitinating enzyme Gammaherpesvirus; Epstein-Barr virus; Kaposi’s sarcoma-associated herpesvirus; KSHV; EBV; viral FGARAT; PML nuclear bodies; ubiquitin; proteasome; deubiquitinating enzyme
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Full, F.; Hahn, A.S.; Großkopf, A.K.; Ensser, A. Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System. Viruses 2017, 9, 308.

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