Next Article in Journal
Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import
Next Article in Special Issue
A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology
Previous Article in Journal
Hepatitis B Virus and DNA Damage Response: Interactions and Consequences for the Infection
Previous Article in Special Issue
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4+ T Cells
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Viruses 2017, 9(10), 303; https://doi.org/10.3390/v9100303

The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis

1
Département of Microbiologie, Infectiologie et Immunologie and Centre de Recherche du CHUM, Faculté de Médecine, Université de Montréal, Montréal, QC H2X 0A9, Canada
2
Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
3
Chronic Viral Illness Service and Division of Hematology, McGill University Health Centre, Montréal, QC H4A 3J1, Canada
*
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 11 October 2017 / Accepted: 13 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Homage to Mark Wainberg)
View Full-Text   |   Download PDF [677 KB, uploaded 19 October 2017]   |  

Abstract

The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and adaptive immunity against fungal and bacterial infections at skin and mucosal barrier surfaces. Although Th17 cells have been extensively studied in the context of autoimmunity, their role in various other pathologies is underexplored and remains an area of open investigation. This review summarizes the history of Th17 cell discovery and the current knowledge relative to the beneficial role of Th17 cells in maintaining mucosal immunity homeostasis. We further discuss the concept of Th17 pathogenicity in the context of autoimmunity, cancer, and HIV infection, and we review the most recent discoveries on molecular mechanisms regulating HIV replication/persistence in pathogenic Th17 cells. Finally, we stress the need for novel fundamental research discovery-based Th17-specific therapeutic interventions to treat pathogenic conditions associated with Th17 abnormalities, including HIV infection. View Full-Text
Keywords: Th17 cells; CCR6; autoimmunity; cancer; HIV-1; gut; antiretroviral therapy Th17 cells; CCR6; autoimmunity; cancer; HIV-1; gut; antiretroviral therapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Wacleche, V.S.; Landay, A.; Routy, J.-P.; Ancuta, P. The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis. Viruses 2017, 9, 303.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top