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Viruses 2016, 8(5), 147; doi:10.3390/v8050147

Biological Characteristics of Experimental Genotype Mixtures of Cydia Pomonella Granulovirus (CpGV): Ability to Control Susceptible and Resistant Pest Populations

1
LGEI, Ecole des Mines d’Alès, Institut Mines-Telecom et Université de Montpellier Sud de France, 6 Avenue de Clavières, 30319 Alès, France
2
Natural Plant Protection, Arysta LifeScience Group, Avenue Léon Blum, 64000 Pau, France
3
INRA, 6, Avenue de Clavières, 30319 Alès, France
4
INRA, unité PSH, Agroparc, 84914 AVIGNON Cedex 9, France
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 12 November 2015 / Revised: 9 May 2016 / Accepted: 11 May 2016 / Published: 21 May 2016
(This article belongs to the Section Insect Viruses)
View Full-Text   |   Download PDF [1274 KB, uploaded 21 May 2016]   |  

Abstract

The detection of resistance in codling moth (Cydia pomonella) populations against the Mexican isolate of its granulovirus (CpGV-M), raised questions on the sustainability of the use of this biological insecticide. In resistant host cells, CpGV-M is not able to complete its replication cycle because replication is blocked at an early step. Virus isolates able to overcome this resistance have been characterized—among them, the CpGV-R5 isolate. In mixed infections on resistant insects, both CpGV-M and CpGV-R5 viruses replicate, while CpGV-M alone does not induce mortality. Genetically heterogeneous virus populations, containing 50% of each CpGV-M and CpGV-R5 appear to control resistant host populations as well as CpGV-R5 alone at the same final concentration, even if the concentration of CpGV-R5 is only half in the former. The use of mixed genotype virus preparations instead of genotypically homogeneous populations may constitute a better approach than traditional methods for the development of baculovirus-based biological insecticides. View Full-Text
Keywords: CpGV; Lepidoptera; genetic heterogeneity; resistance; biological control CpGV; Lepidoptera; genetic heterogeneity; resistance; biological control
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MDPI and ACS Style

Graillot, B.; Bayle, S.; Blachere-Lopez, C.; Besse, S.; Siegwart, M.; Lopez-Ferber, M. Biological Characteristics of Experimental Genotype Mixtures of Cydia Pomonella Granulovirus (CpGV): Ability to Control Susceptible and Resistant Pest Populations. Viruses 2016, 8, 147.

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