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Viruses 2016, 8(4), 106; doi:10.3390/v8040106

Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
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Author to whom correspondence should be addressed.
Academic Editors: Jane Tao and Pierre-Yves Lozach
Received: 8 March 2016 / Revised: 15 April 2016 / Accepted: 18 April 2016 / Published: 21 April 2016
(This article belongs to the Special Issue Recent Progress in Bunyavirus Research)
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Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research. View Full-Text
Keywords: Crimean-Congo hemorrhagic fever; viral hemorrhagic fever; reverse genetics; pathogenesis; tick-borne virus Crimean-Congo hemorrhagic fever; viral hemorrhagic fever; reverse genetics; pathogenesis; tick-borne virus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zivcec, M.; Scholte, F.E.M.; Spiropoulou, C.F.; Spengler, J.R.; Bergeron, É. Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. Viruses 2016, 8, 106.

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