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Viruses 2016, 8(12), 337; doi:10.3390/v8120337

Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity

1
Department of Immunology and Microbial Science the Scripps Research Institute, La Jolla, CA 92037, USA
2
Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Jason Mercer
Received: 12 October 2016 / Revised: 15 December 2016 / Accepted: 16 December 2016 / Published: 21 December 2016
(This article belongs to the Special Issue Virus Uncoating and Nuclear Import)
View Full-Text   |   Download PDF [3258 KB, uploaded 21 December 2016]   |  

Abstract

Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules. View Full-Text
Keywords: adenovirus; AFM; capsid disassembly; integrins; defensins; cryoelectron microscopy; antibody; neutralization; nuclear pore; dynein; hexon; penton base; protein VI; ts1; cysteine protease; nuclear porins; microtubules; adenovirus receptors adenovirus; AFM; capsid disassembly; integrins; defensins; cryoelectron microscopy; antibody; neutralization; nuclear pore; dynein; hexon; penton base; protein VI; ts1; cysteine protease; nuclear porins; microtubules; adenovirus receptors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nemerow, G.R.; Stewart, P.L. Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity. Viruses 2016, 8, 337.

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