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Viruses 2016, 8(10), 284; doi:10.3390/v8100284

Gene Regulation and Quality Control in Murine Polyomavirus Infection

Department of Genetics and Genome Sciences, UCONN Health, Farmington, CT 06030, USA
Academic Editors: J. Robert Hogg and Karen L. Beemon
Received: 19 September 2016 / Revised: 10 October 2016 / Accepted: 11 October 2016 / Published: 17 October 2016
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
View Full-Text   |   Download PDF [2137 KB, uploaded 17 October 2016]   |  

Abstract

Murine polyomavirus (MPyV) infects mouse cells and is highly oncogenic in immunocompromised hosts and in other rodents. Its genome is a small, circular DNA molecule of just over 5000 base pairs and it encodes only seven polypeptides. While seemingly simply organized, this virus has adopted an unusual genome structure and some unusual uses of cellular quality control pathways that, together, allow an amazingly complex and varied pattern of gene regulation. In this review we discuss how MPyV leverages these various pathways to control its life cycle. View Full-Text
Keywords: quality control; transcription; RNA decay; RNA editing; nuclear retention quality control; transcription; RNA decay; RNA editing; nuclear retention
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Carmichael, G.G. Gene Regulation and Quality Control in Murine Polyomavirus Infection. Viruses 2016, 8, 284.

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