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Viruses 2015, 7(9), 5084-5114; doi:10.3390/v7092861

Tegument Assembly and Secondary Envelopment of Alphaherpesviruses

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
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Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Revised: 22 August 2015 / Accepted: 26 August 2015 / Published: 18 September 2015
(This article belongs to the Special Issue Viruses and Exosomes)
View Full-Text   |   Download PDF [2568 KB, uploaded 18 September 2015]   |  

Abstract

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their ability to establish lifelong latent infection in neurons. As for all herpesviruses, alphaherpesvirus virions contain a protein-rich layer called “tegument” that links the DNA-containing capsid to the glycoprotein-studded membrane envelope. Tegument proteins mediate a diverse range of functions during the virus lifecycle, including modulation of the host-cell environment immediately after entry, transport of virus capsids to the nucleus during infection, and wrapping of cytoplasmic capsids with membranes (secondary envelopment) during virion assembly. Eleven tegument proteins that are conserved across alphaherpesviruses have been implicated in the formation of the tegument layer or in secondary envelopment. Tegument is assembled via a dense network of interactions between tegument proteins, with the redundancy of these interactions making it challenging to determine the precise function of any specific tegument protein. However, recent studies have made great headway in defining the interactions between tegument proteins, conserved across alphaherpesviruses, which facilitate tegument assembly and secondary envelopment. We summarize these recent advances and review what remains to be learned about the molecular interactions required to assemble mature alphaherpesvirus virions following the release of capsids from infected cell nuclei. View Full-Text
Keywords: virus egress; virus maturation; herpes simplex virus; HSV-1; pseudorabies virus; PrV virus egress; virus maturation; herpes simplex virus; HSV-1; pseudorabies virus; PrV
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Owen, D.J.; Crump, C.M.; Graham, S.C. Tegument Assembly and Secondary Envelopment of Alphaherpesviruses. Viruses 2015, 7, 5084-5114.

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