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Viruses 2015, 7(8), 4352-4368; doi:10.3390/v7082824

Vpu Protein: The Viroporin Encoded by HIV-1

Unidad de Expresión Viral, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera de Majadahonda-Pozuelo Km 2, Majadahonda, Madrid 28220, Spain
Academic Editor: José Luis Nieva
Received: 29 June 2015 / Revised: 29 June 2015 / Accepted: 28 July 2015 / Published: 4 August 2015
(This article belongs to the Special Issue Viroporins)
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Abstract

Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. Notwithstanding the high variability of its amino acid sequence, the functionality of Vpu is well conserved in pandemic virus isolates. This review outlines our current knowledge on the interactions of Vpu with the host cell. The regulation of cellular physiology by Vpu and the validity of this viroporin as a therapeutic target are also discussed. View Full-Text
Keywords: Vpu; HIV-1; Viroporin; protein trafficking; membrane permeability; ion transport; membrane pore; antiretroviral target Vpu; HIV-1; Viroporin; protein trafficking; membrane permeability; ion transport; membrane pore; antiretroviral target
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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González, M.E. Vpu Protein: The Viroporin Encoded by HIV-1. Viruses 2015, 7, 4352-4368.

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