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Viruses 2015, 7(7), 4047-4074; doi:10.3390/v7072805

The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis

Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
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Author to whom correspondence should be addressed.
Academic Editor: Louis M. Mansky
Received: 11 June 2015 / Revised: 30 June 2015 / Accepted: 7 July 2015 / Published: 20 July 2015
(This article belongs to the Special Issue Recent Advances in HTLV Research 2015)
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Abstract

Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Distinct mechanisms such as transcriptional, epigenetic or interference with miRNA processing machinery have been involved. This article reviews the current knowledge of the role of cellular microRNAs in virus infection, replication, immune escape and pathogenesis of HTLV-1. View Full-Text
Keywords: human; HTLV-I infections; T-lymphotrophic virus 1; leukemia-lymphoma; adult T-cell; microRNAs; virus replication; cell line; cell transformation; gene expression regulation human; HTLV-I infections; T-lymphotrophic virus 1; leukemia-lymphoma; adult T-cell; microRNAs; virus replication; cell line; cell transformation; gene expression regulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moles, R.; Nicot, C. The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis. Viruses 2015, 7, 4047-4074.

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