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Viruses 2015, 7(7), 3768-3788; doi:10.3390/v7072796

Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases

School of Life Sciences, University of Warwick, Coventry CV4-7AL, UK
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Author to whom correspondence should be addressed.
Academic Editor: Andrew Mehle
Received: 3 May 2015 / Revised: 27 June 2015 / Accepted: 3 July 2015 / Published: 8 July 2015
(This article belongs to the Special Issue Gene Technology and Resistance to Viruses - Reviews)
View Full-Text   |   Download PDF [307 KB, uploaded 8 July 2015]   |  

Abstract

Defective interfering (DI) genomes are characterised by their ability to interfere with the replication of the virus from which they were derived, and other genetically compatible viruses. DI genomes are synthesized by nearly all known viruses and represent a vast natural reservoir of antivirals that can potentially be exploited for use in the clinic. This review describes the application of DI virus to protect from virus-associated diseases in vivo using as an example a highly active cloned influenza A DI genome and virus that protects broadly in preclinical trials against different subtypes of influenza A and against non-influenza A respiratory viruses. This influenza A-derived DI genome protects by two totally different mechanisms: molecular interference with influenza A replication and by stimulating innate immunity that acts against non-influenza A viruses. The review considers what is needed to develop DI genomes to the point of entry into clinical trials. View Full-Text
Keywords: defective interfering RNA; influenza virus; respiratory disease; treatment; therapy; prophylaxis; antivirals defective interfering RNA; influenza virus; respiratory disease; treatment; therapy; prophylaxis; antivirals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dimmock, N.J.; Easton, A.J. Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases. Viruses 2015, 7, 3768-3788.

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