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Viruses 2015, 7(7), 3380-3391; doi:10.3390/v7072777

NLRP3 Inflammasome Activation by Viroporins of Animal Viruses

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: José Luis Nieva and Luis Carrasco
Received: 23 April 2015 / Revised: 15 June 2015 / Accepted: 17 June 2015 / Published: 24 June 2015
(This article belongs to the Special Issue Viroporins)
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Abstract

Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly, as well as viral particle entry and release. Viroporins also play an important role in the regulation of antiviral innate immune responses, especially in inflammasome formation and activation, to ensure the completion of the viral life cycle. By reviewing the research progress made in recent years on the regulation of the NLRP3 inflammasome by viroporins of animal viruses, we aim to understand the importance of viroporins in viral infection and to provide a reference for further research and development of novel antiviral drugs. View Full-Text
Keywords: viroporin; inflammasome; NLRP3; animal virus viroporin; inflammasome; NLRP3; animal virus
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MDPI and ACS Style

Guo, H.-C.; Jin, Y.; Zhi, X.-Y.; Yan, D.; Sun, S.-Q. NLRP3 Inflammasome Activation by Viroporins of Animal Viruses. Viruses 2015, 7, 3380-3391.

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