Next Article in Journal
Molecular Characterization of a Novel Positive-Sense, Single-Stranded RNA Mycovirus Infecting the Plant Pathogenic Fungus Sclerotinia sclerotiorum
Next Article in Special Issue
High-Risk Human Papillomavirus Targets Crossroads in Immune Signaling
Previous Article in Journal / Special Issue
Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression
Article Menu

Export Article

Open AccessReview
Viruses 2015, 7(5), 2450-2469; doi:10.3390/v7052450

The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Joanna Parish
Received: 27 March 2015 / Accepted: 13 May 2015 / Published: 21 May 2015
(This article belongs to the Special Issue Tumour Viruses)
View Full-Text   |   Download PDF [586 KB, uploaded 21 May 2015]   |  

Abstract

The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection. View Full-Text
Keywords: HPV; papillomavirus; replication; DNA damage response; homologous recombination; keratinocyte; replication foci; DNA repair; partitioning; episome HPV; papillomavirus; replication; DNA damage response; homologous recombination; keratinocyte; replication foci; DNA repair; partitioning; episome
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

McKinney, C.C.; Hussmann, K.L.; McBride, A.A. The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle. Viruses 2015, 7, 2450-2469.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top