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Viruses 2015, 7(5), 2321-2333; doi:10.3390/v7052321

Alphaviruses in Gene Therapy

PanTherapeutics, Lutry CH1095, Switzerland
Academic Editor: Eric O. Freed
Received: 4 March 2015 / Revised: 15 April 2015 / Accepted: 23 April 2015 / Published: 7 May 2015
(This article belongs to the Special Issue Gene Therapy with Emphasis on RNA Interference)
View Full-Text   |   Download PDF [690 KB, uploaded 12 May 2015]   |  

Abstract

Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction. Mainly three types of alphavirus vectors, namely naked RNA, recombinant particles and DNA/RNA layered vectors, have been subjected to preclinical studies with the goal of achieving prophylactic or therapeutic efficacy, particularly in oncology. In this context, immunization with alphavirus vectors has provided protection against challenges with tumor cells. Moreover, alphavirus intratumoral and systemic delivery has demonstrated substantial tumor regression and significant prolonged survival rates in various animal tumor models. Recent discoveries of the strong association of RNA interference and disease have accelerated gene therapy based approaches, where alphavirus-based gene delivery can play an important role. View Full-Text
Keywords: alpahvirus; vector delivery; cancer; vaccines; gene therapy; RNA interference; micro-RNA alpahvirus; vector delivery; cancer; vaccines; gene therapy; RNA interference; micro-RNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lundstrom, K. Alphaviruses in Gene Therapy. Viruses 2015, 7, 2321-2333.

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