Next Article in Journal
Evaluation of ViroCyt® Virus Counter for Rapid Filovirus Quantitation
Previous Article in Journal
The Role of RNA Interference (RNAi) in Arbovirus-Vector Interactions
Article Menu

Export Article

Open AccessShort Communication
Viruses 2015, 7(2), 844-856; doi:10.3390/v7020844

Complete Genome Analysis of a Rabbit Rotavirus Causing Gastroenteritis in a Human Infant

KU Leuven-University of Leuven, Department of Microbiology and Immunology, Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, B-3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 20 January 2015 / Revised: 10 February 2015 / Accepted: 13 February 2015 / Published: 17 February 2015
View Full-Text   |   Download PDF [787 KB, uploaded 12 May 2015]   |  

Abstract

Group A rotaviruses (RVA) are responsible for causing infantile diarrhea both in humans and animals. The molecular characteristics of lapine RVA strains are only studied to a limited extent and so far G3P[14] and G3P[22] were found to be the most common G/P-genotypes. During the 2012-2013 rotavirus season in Belgium, a G3P[14] RVA strain was isolated from stool collected from a two-year-old boy. We investigated whether RVA/Human-wt/BEL/BE5028/2012/G3P[14] is completely of lapine origin or the result of reassortment event(s). Phylogenetic analyses of all gene segments revealed the following genotype constellation: G3-P[14]-I2-R2-C2-M3-A9-N2-T6-E5-H3 and indicated that BE5028 probably represents a rabbit to human interspecies transmission able to cause disease in a human child. Interestingly, BE5028 showed a close evolutionary relationship to RVA/Human-wt/BEL/B4106/2000/G3P[14], another lapine-like strain isolated in a Belgian child in 2000. The phylogenetic analysis of the NSP3 segment suggests the introduction of a bovine(-like) NSP3 into the lapine RVA population in the past 12 years. Sequence analysis of NSP5 revealed a head-to-tail partial duplication, combined with two short insertions and a deletion, indicative of the continuous circulation of this RVA lineage within the rabbit population. View Full-Text
Keywords: group A rotavirus; rabbit to human interspecies transmission; G3P[14]; complete genome characterization group A rotavirus; rabbit to human interspecies transmission; G3P[14]; complete genome characterization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bonica, M.B.; Zeller, M.; Van Ranst, M.; Matthijnssens, J.; Heylen, E. Complete Genome Analysis of a Rabbit Rotavirus Causing Gastroenteritis in a Human Infant. Viruses 2015, 7, 844-856.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top