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Viruses 2015, 7(2), 739-750; doi:10.3390/v7020739

eIF4E as a Control Target for Viruses

1
Public Health Institute, University of Veracruz, Veracruz 91190, Mexico
2
Preparative Procedures and Access to Proteomic Services Unit, Institute of Biomedical Research, National Autonomous University of Mexico. Distrito Federal 04510, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 12 December 2014 / Revised: 6 February 2015 / Accepted: 11 February 2015 / Published: 16 February 2015
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Abstract

Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves. View Full-Text
Keywords: eIF4E; 4EBP; virus; translation; latency; cancer eIF4E; 4EBP; virus; translation; latency; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Montero, H.; García-Román, R.; Mora, S.I. eIF4E as a Control Target for Viruses. Viruses 2015, 7, 739-750.

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