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Viruses 2015, 7(12), 6400-6411; doi:10.3390/v7122947

Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China

Department of Virology, School of Public Health, Shandong University, Jinan 250012, China
Shandong Center for Disease Control and Prevention, Jinan 250014, China
Qilu Hospital of Shandong University, Jinan 250012, China
Center for Biodefense and Emerging Infectious Diseases, Departments of Pathology and Microbiology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: George Belov
Received: 21 September 2015 / Revised: 27 November 2015 / Accepted: 1 December 2015 / Published: 7 December 2015
(This article belongs to the Special Issue Recent Progress in Enterovirus Research)
View Full-Text   |   Download PDF [1360 KB, uploaded 7 December 2015]   |  


Hand, foot, and mouth disease (HFMD), which has led to millions of attacks and several outbreaks across the world and become more predominant in Asia-Pacific Region, especially in Mainland China, is caused by several Human Enteroviruses including new enterovirus, coxsakievirus and echovirus. In recent years, much research has focused on the epidemiological characteristics of HFMD. In this article, multiple characteristics of HFMD such as basic epidemiology, etiology and molecular epidemiology; influencing factors; detection; and surveillance are reviewed, as these can be help protect high risks groups, prevalence prediction and policy making for disease prevention. View Full-Text
Keywords: HFMD; enterovirus; epidemiology; etiology; influencing factor HFMD; enterovirus; epidemiology; etiology; influencing factor

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhuang, Z.-C.; Kou, Z.-Q.; Bai, Y.-J.; Cong, X.; Wang, L.-H.; Li, C.; Zhao, L.; Yu, X.-J.; Wang, Z.-Y.; Wen, H.-L. Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China. Viruses 2015, 7, 6400-6411.

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