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Correction published on 18 May 2016, see Viruses 2016, 8(5), 137.

Open AccessBrief Report
Viruses 2015, 7(12), 6233-6240; doi:10.3390/v7122934

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

1
Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, France
2
Host Pathogen interaction during lentiviral infection, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, France
*
Author to whom correspondence should be addressed.
Academic Editor: Jens H. Kuhn
Received: 9 July 2015 / Revised: 16 November 2015 / Accepted: 18 November 2015 / Published: 1 December 2015
(This article belongs to the Collection Advances in Ebolavirus, Marburgvirus, and Cuevavirus Research)
View Full-Text   |   Download PDF [917 KB, uploaded 18 May 2016]   |  

Abstract

The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV. View Full-Text
Keywords: Ebola; Marburg; Filovirus; polymerase; antiviral; inhibitors Ebola; Marburg; Filovirus; polymerase; antiviral; inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Reynard, O.; Nguyen, X.-N.; Alazard-Dany, N.; Barateau, V.; Cimarelli, A.; Volchkov, V.E. Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication. Viruses 2015, 7, 6233-6240.

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