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Viruses 2015, 7(12), 6604-6612; doi:10.3390/v7122960

Recent Advances in Therapeutic Approaches for Adult T-cell Leukemia/Lymphoma

Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Louis M. Mansky
Received: 30 September 2015 / Revised: 29 November 2015 / Accepted: 3 December 2015 / Published: 14 December 2015
(This article belongs to the Special Issue Recent Advances in HTLV Research 2015)
View Full-Text   |   Download PDF [187 KB, uploaded 14 December 2015]

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell lymphoma caused by human T-cell leukemia/lymphoma virus type 1 (HTLV-1). ATLL occurs in approximately 3%–5% of HTLV-1 carriers during their lifetime and follows a heterogeneous clinical course. The Shimoyama classification has been frequently used for treatment decisions in ATLL patients, and antiviral therapy has been reportedly promising, particularly in patients with indolent type ATLL; however, the prognosis continues to be dismal for patients with aggressive-type ATLL. Recent efforts to improve treatment outcomes have been focused on the development of prognostic stratification and improved dosage, timing, and combination of therapeutic modalities, such as antiviral therapy, chemotherapy, allogeneic hematopoietic stem cell transplantation, and molecular targeted therapy. View Full-Text
Keywords: adult T-cell leukemia/lymphoma; allogeneic hematopoietic stem cell transplantation; graft-versus-host disease; mogamulizumab; chemotherapy; antiviral therapy; J0101 adult T-cell leukemia/lymphoma; allogeneic hematopoietic stem cell transplantation; graft-versus-host disease; mogamulizumab; chemotherapy; antiviral therapy; J0101
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kato, K.; Akashi, K. Recent Advances in Therapeutic Approaches for Adult T-cell Leukemia/Lymphoma. Viruses 2015, 7, 6604-6612.

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