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Viruses 2015, 7(11), 6080-6088; doi:10.3390/v7112929

Recent Advances in BLV Research

1
Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium
2
Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, Castelar C.C. 1712, Argentina
3
Department of Pathology, National Veterinary Research Institute, Pulawy 24-110, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Louis Mansky
Received: 28 September 2015 / Accepted: 19 November 2015 / Published: 24 November 2015
(This article belongs to the Special Issue Recent Advances in HTLV Research 2015)
View Full-Text   |   Download PDF [550 KB, uploaded 24 November 2015]   |  

Abstract

Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies. View Full-Text
Keywords: BLV; HTLV-1; Tax; microRNA; vaccine; HDAC BLV; HTLV-1; Tax; microRNA; vaccine; HDAC
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Barez, P.-Y.; de Brogniez, A.; Carpentier, A.; Gazon, H.; Gillet, N.; Gutiérrez, G.; Hamaidia, M.; Jacques, J.-R.; Perike, S.; Neelature Sriramareddy, S.; Renotte, N.; Staumont, B.; Reichert, M.; Trono, K.; Willems, L. Recent Advances in BLV Research. Viruses 2015, 7, 6080-6088.

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