Next Article in Journal
HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells
Previous Article in Journal
Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance
Article Menu

Export Article

Open AccessArticle
Viruses 2015, 7(10), 5225-5242; doi:10.3390/v7102870

Isolation and Genome Characterization of the Virulent Staphylococcus aureus Bacteriophage SA97

1
Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul 151-921, Korea
2
Department of Food Science and Biotechnology, Kyung Hee University, Yongin 446-701, Korea
3
Department of Dermatology, College of Medicine, the Catholic University of Korea, Seoul 137-701, Korea
4
Department of Microbiology, College of Medicine, the Catholic University of Korea, Seoul 137-701, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Rob Lavigne
Received: 21 July 2015 / Revised: 31 August 2015 / Accepted: 22 September 2015 / Published: 1 October 2015
(This article belongs to the Section Bacterial Viruses)
View Full-Text   |   Download PDF [3163 KB, uploaded 1 October 2015]   |  

Abstract

A novel bacteriophage that infects S. aureus, SA97, was isolated and characterized. The phage SA97 belongs to the Siphoviridae family, and the cell wall teichoic acid (WTA) was found to be a host receptor of the phage SA97. Genome analysis revealed that SA97 contains 40,592 bp of DNA encoding 54 predicted open reading frames (ORFs), and none of these genes were related to virulence or drug resistance. Although a few genes associated with lysogen formation were detected in the phage SA97 genome, the phage SA97 produced neither lysogen nor transductant in S. aureus. These results suggest that the phage SA97 may be a promising candidate for controlling S. aureus. View Full-Text
Keywords: bacteriophage; genome analysis; Staphylococcus aureus bacteriophage; genome analysis; Staphylococcus aureus
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chang, Y.; Shin, H.; Lee, J.-H.; Park, C.J.; Paik, S.-Y.; Ryu, S. Isolation and Genome Characterization of the Virulent Staphylococcus aureus Bacteriophage SA97. Viruses 2015, 7, 5225-5242.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top