Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?
AbstractStudies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention. View Full-Text
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Royle, J.; Dobson, S.J.; Müller, M.; Macdonald, A. Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? Viruses 2015, 7, 5375-5387.
Royle J, Dobson SJ, Müller M, Macdonald A. Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? Viruses. 2015; 7(10):5375-5387.Chicago/Turabian Style
Royle, Jamie; Dobson, Samuel J.; Müller, Marietta; Macdonald, Andrew. 2015. "Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?" Viruses 7, no. 10: 5375-5387.