Next Article in Journal
The Ins and Outs of Viral Infection: Keystone Meeting Review
Previous Article in Journal
Retroviral Vectors for Analysis of Viral Mutagenesis and Recombination
Article Menu

Export Article

Open AccessCommentary
Viruses 2014, 6(9), 3643-3651; doi:10.3390/v6093643

Stepping toward a Macaque Model of HIV-1 Induced AIDS

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM385, Houston, TX 77030, USA
Received: 6 August 2014 / Revised: 16 September 2014 / Accepted: 18 September 2014 / Published: 25 September 2014
(This article belongs to the Section Editorial)
View Full-Text   |   Download PDF [275 KB, uploaded 12 May 2015]   |  

Abstract

HIV-1 exhibits a narrow host range, hindering the development of a robust animal model of pathogenesis. Past studies have demonstrated that the restricted host range of HIV-1 may be largely due to the inability of the virus to antagonize and evade effector molecules of the interferon response in other species. They have also guided the engineering of HIV-1 clones that can replicate in CD4 T-cells of Asian macaque species. However, while replication of these viruses in macaque hosts is persistent, it has been limited and without progression to AIDS. In a new study, Hatziioannou et al., demonstrate for the first time that adapted macaque-tropic HIV-1 can persistently replicate at high levels in pigtailed macaques (Macaca nemestrina), but only if CD8 T-cells are depleted at the time of inoculation. The infection causes rapid disease and recapitulates several aspects of AIDS in humans. Additionally, the virus undergoes genetic changes to further escape innate immunity in association with disease progression. Here, the importance of these findings is discussed, as they relate to pathogenesis and model development. View Full-Text
Keywords: HIV-1; Macaca nemestrina; pathogenesis; AIDS; innate restriction HIV-1; Macaca nemestrina; pathogenesis; AIDS; innate restriction
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kimata, J.T. Stepping toward a Macaque Model of HIV-1 Induced AIDS. Viruses 2014, 6, 3643-3651.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top