Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease
AbstractKaposi’s sarcoma-associated herpesvirus (KSHV, also named Human herpesvirus 8 HHV-8) is the cause of Kaposi sarcoma (KS), the most common malignancy in HIV-infected individuals worldwide, primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). KSHV is a double-stranded DNA virus that encodes several homologues of cellular proteins. The structural similarity between viral and host proteins explains why some viral homologues function as their host counterparts, but sometimes at unusual anatomical sites and inappropriate times. In other cases, structural modification in the viral proteins can suppress or override the function of the host homologue, contributing to KSHV-related diseases. For example, viral IL-6 (vIL-6) is sufficiently different from human IL-6 to activate gp130 signaling independent of the α subunit. As a consequence, vIL-6 can activate many cell types that are unresponsive to cellular IL-6, contributing to MCD disease manifestations. Here, we discuss the molecular biology of KSHV homologues of cellular products as conduits of virus/host interaction with a focus on identifying new strategies for therapy of KS and other KSHV-related diseases. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Sakakibara, S.; Tosato, G. Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease. Viruses 2014, 6, 3472-3486.
Sakakibara S, Tosato G. Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease. Viruses. 2014; 6(9):3472-3486.Chicago/Turabian Style
Sakakibara, Shuhei; Tosato, Giovanna. 2014. "Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease." Viruses 6, no. 9: 3472-3486.