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Viruses 2014, 6(11), 4760-4799; doi:10.3390/v6114760

Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014

1
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
2
FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
3
Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Lyon, France
4
Information Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
5
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
6
Centre International de Recherches Médicales de Franceville, B. P. 769, Franceville, Gabon
7
Fondation Mérieux, Washington, DC 20036, USA
8
Bernhard Nocht Institute for Tropical Medicine, World Health Organization (WHO) Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, and the German Center for Infection Research (DZIF), Partner Site Hamburg, 20259 Hamburg, Germany
9
Tulane University School of Medicine, New Orleans, LA 70112, USA
10
Kenema Government Hospital, Kenema, Sierra Leone
11
Metabiota, Inc., San Francisco, CA 94104, USA
12
Department of Biological Sciences, College of Natural Sciences, and African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Mowe, Ogun State, Nigeria
13
Institut National de Recherche Biomédicales, Kinshasa-Gombe BP 1197, Republic of the Congo
14
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
15
Université Gamal Abdel Nasser de Conakry, Laboratoire des fièvres hémorragiques en Guinée, Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, BP 5680, Conakry, Guinea
16
Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
17
Department of Medical Microbiology and Parasitology, College of Medicine of the University of Lagos, Idi-Araba, Private Mail Bag 12003, Lagos, Nigeria
18
The Broad Institute, Cambridge, MA 02142, USA
19
Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham-Johannesburg 2192, Gauteng, South Africa
20
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
21
Zoonoses Research Unit, University of Pretoria, Private bag X20 Hatfield, Pretoria 0028, South Africa
22
World Health Organization, 1211 Geneva, Switzerland
*
Author to whom correspondence should be addressed.
Received: 16 November 2014 / Accepted: 20 November 2014 / Published: 24 November 2014
(This article belongs to the Collection Advances in Ebolavirus, Marburgvirus, and Cuevavirus Research)
View Full-Text   |   Download PDF [832 KB, uploaded 12 May 2015]   |  

Abstract

In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into human populations and that both outbreaks are not directly connected. Coding-complete genomic sequence analyses of isolates revealed that the two outbreaks were caused by two novel EBOV variants, and initial clinical observations suggest that neither of them should be considered strains. Here we present consensus decisions on naming for both variants (West Africa: “Makona”, Middle Africa: “Lomela”) and provide database-compatible full, shortened, and abbreviated names that are in line with recently established filovirus sub-species nomenclatures. View Full-Text
Keywords: Ebola; Ebola virus; ebolavirus; filovirid; Filoviridae; filovirus; genome annotation; Lomela; Lokolia; Makona; mononegavirad; Mononegavirales; mononegavirus; virus classification; virus isolate; virus nomenclature; virus strain; virus taxonomy; virus variant Ebola; Ebola virus; ebolavirus; filovirid; Filoviridae; filovirus; genome annotation; Lomela; Lokolia; Makona; mononegavirad; Mononegavirales; mononegavirus; virus classification; virus isolate; virus nomenclature; virus strain; virus taxonomy; virus variant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kuhn, J.H.; Andersen, K.G.; Baize, S.; Bào, Y.; Bavari, S.; Berthet, N.; Blinkova, O.; Brister, J.R.; Clawson, A.N.; Fair, J.; Gabriel, M.; Garry, R.F.; Gire, S.K.; Goba, A.; Gonzalez, J.-P.; Günther, S.; Happi, C.T.; Jahrling, P.B.; Kapetshi, J.; Kobinger, G.; Kugelman, J.R.; Leroy, E.M.; Maganga, G.D.; Mbala, P.K.; Moses, L.M.; Muyembe-Tamfum, J.-J.; N'Faly, M.; Nichol, S.T.; Omilabu, S.A.; Palacios, G.; Park, D.J.; Paweska, J.T.; Radoshitzky, S.R.; Rossi, C.A.; Sabeti, P.C.; Schieffelin, J.S.; Schoepp, R.J.; Sealfon, R.; Swanepoel, R.; Towner, J.S.; Wada, J.; Wauquier, N.; Yozwiak, N.L.; Formenty, P. Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014. Viruses 2014, 6, 4760-4799.

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