Next Article in Journal
Mosquito Immunity against Arboviruses
Previous Article in Journal
Host Control of Insect Endogenous Retroviruses: Small RNA Silencing and Immune Response
Article Menu

Export Article

Open AccessArticle
Viruses 2014, 6(11), 4465-4478; doi:10.3390/v6114465

Analysis of Adaptive Evolution in Lyssavirus Genomes Reveals Pervasive Diversifying Selection during Species Diversification

Department of Genetics, Federal University of Rio de Janeiro, CEP: 21941-617, Brazil
*
Author to whom correspondence should be addressed.
Received: 2 September 2014 / Revised: 24 October 2014 / Accepted: 11 November 2014 / Published: 19 November 2014
(This article belongs to the Section Animal Viruses)
View Full-Text   |   Download PDF [1163 KB, uploaded 12 May 2015]   |  

Abstract

Lyssavirus is a diverse genus of viruses that infect a variety of mammalian hosts, typically causing encephalitis. The evolution of this lineage, particularly the rabies virus, has been a focus of research because of the extensive occurrence of cross-species transmission, and the distinctive geographical patterns present throughout the diversification of these viruses. Although numerous studies have examined pattern-related questions concerning Lyssavirus evolution, analyses of the evolutionary processes acting on Lyssavirus diversification are scarce. To clarify the relevance of positive natural selection in Lyssavirus diversification, we conducted a comprehensive scan for episodic diversifying selection across all lineages and codon sites of the five coding regions in lyssavirus genomes. Although the genomes of these viruses are generally conserved, the glycoprotein (G), RNA-dependent RNA polymerase (L) and polymerase (P) genes were frequently targets of adaptive evolution during the diversification of the genus. Adaptive evolution is particularly manifest in the glycoprotein gene, which was inferred to have experienced the highest density of positively selected codon sites along branches. Substitutions in the L gene were found to be associated with the early diversification of phylogroups. A comparison between the number of positively selected sites inferred along the branches of RABV population branches and Lyssavirus intespecies branches suggested that the occurrence of positive selection was similar on the five coding regions of the genome in both groups. View Full-Text
Keywords: rabies virus; molecular adaptation; positive selection; Chiroptera rabies virus; molecular adaptation; positive selection; Chiroptera
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Voloch, C.M.; Capellão, R.T.; Mello, B.; Schrago, C.G. Analysis of Adaptive Evolution in Lyssavirus Genomes Reveals Pervasive Diversifying Selection during Species Diversification. Viruses 2014, 6, 4465-4478.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top