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Viruses 2013, 5(12), 2963-2976; doi:10.3390/v5122963
Review

Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity

 and *
Received: 21 October 2013; in revised form: 20 November 2013 / Accepted: 25 November 2013 / Published: 2 December 2013
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Abstract: Equine infectious anemia (EIA), identified in 1843 [1] as an infectious disease of horses and as a viral infection in 1904, remains a concern in veterinary medicine today. Equine infectious anemia virus (EIAV) has served as an animal model of HIV-1/AIDS research since the original identification of HIV. Similar to other lentiviruses, EIAV has a high propensity for genomic sequence and antigenic variation, principally in its envelope (Env) proteins. However, EIAV possesses a unique and dynamic disease presentation that has facilitated comprehensive analyses of the interactions between the evolving virus population, progressive host immune responses, and the definition of viral and host correlates of immune control and vaccine efficacy. Summarized here are key findings in EIAV that have provided important lessons toward understanding long term immune control of lentivirus infections and the parameters for development of an enduring broadly protective AIDS vaccine.
Keywords: EIAV; lentivirus; pathogenesis; envelope diversity; vaccine development; immune maturation EIAV; lentivirus; pathogenesis; envelope diversity; vaccine development; immune maturation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Craigo, J.K.; Montelaro, R.C. Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity. Viruses 2013, 5, 2963-2976.

AMA Style

Craigo JK, Montelaro RC. Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity. Viruses. 2013; 5(12):2963-2976.

Chicago/Turabian Style

Craigo, Jodi K.; Montelaro, Ronald C. 2013. "Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity." Viruses 5, no. 12: 2963-2976.



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