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Viruses 2013, 5(12), 2963-2976; doi:10.3390/v5122963

Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity

Center for Vaccine Research, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
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Received: 21 October 2013 / Revised: 20 November 2013 / Accepted: 25 November 2013 / Published: 2 December 2013
(This article belongs to the Section Animal Viruses)
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Abstract

Equine infectious anemia (EIA), identified in 1843 [1] as an infectious disease of horses and as a viral infection in 1904, remains a concern in veterinary medicine today. Equine infectious anemia virus (EIAV) has served as an animal model of HIV-1/AIDS research since the original identification of HIV. Similar to other lentiviruses, EIAV has a high propensity for genomic sequence and antigenic variation, principally in its envelope (Env) proteins. However, EIAV possesses a unique and dynamic disease presentation that has facilitated comprehensive analyses of the interactions between the evolving virus population, progressive host immune responses, and the definition of viral and host correlates of immune control and vaccine efficacy. Summarized here are key findings in EIAV that have provided important lessons toward understanding long term immune control of lentivirus infections and the parameters for development of an enduring broadly protective AIDS vaccine. View Full-Text
Keywords: EIAV; lentivirus; pathogenesis; envelope diversity; vaccine development; immune maturation EIAV; lentivirus; pathogenesis; envelope diversity; vaccine development; immune maturation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Craigo, J.K.; Montelaro, R.C. Lessons in AIDS Vaccine Development Learned from Studies of Equine Infectious, Anemia Virus Infection and Immunity. Viruses 2013, 5, 2963-2976.

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