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Potential Vaccines and Post-Exposure Treatments for Filovirus Infections
United States Army Medical Research Institute of Infectious Diseases, Division of Virology, 1425 Porter Street, Frederick, MD 21702, USA
United States Food and Drug Administration (FDA), Medical Science Countermeasures Initiative (McMi), 10903 New Hampshire Avenue, Silver Spring, MD 20901, USA
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 20 July 2012; in revised form: 31 August 2012 / Accepted: 4 September 2012 / Published: 20 September 2012
Abstract: Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral infection, there remain no sanctioned therapeutic or vaccine strategies. Current progress in the development of filovirus therapeutics and vaccines is outlined herein with respect to their current level of testing, evaluation, and proximity toward human implementation, specifically with regard to human clinical trials, nonhuman primate studies, small animal studies, and in vitro development. Contemporary methods of supportive care and previous treatment approaches for human patients are also discussed.
Keywords: filovirus; Ebola; ebolavirus; Marburg virus; marburgvirus; vaccines; post-exposure treatments; clinical trials; non-human primates; animal models
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Friedrich, B.M.; Trefry, J.C.; Biggins, J.E.; Hensley, L.E.; Honko, A.N.; Smith, D.R.; Olinger, G.G. Potential Vaccines and Post-Exposure Treatments for Filovirus Infections. Viruses 2012, 4, 1619-1650.
Friedrich BM, Trefry JC, Biggins JE, Hensley LE, Honko AN, Smith DR, Olinger GG. Potential Vaccines and Post-Exposure Treatments for Filovirus Infections. Viruses. 2012; 4(9):1619-1650.
Friedrich, Brian M.; Trefry, John C.; Biggins, Julia E.; Hensley, Lisa E.; Honko, Anna N.; Smith, Darci R.; Olinger, Gene G. 2012. "Potential Vaccines and Post-Exposure Treatments for Filovirus Infections." Viruses 4, no. 9: 1619-1650.