Viruses 2012, 4(9), 1509-1514; doi:10.3390/v4091509
Review

Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?

Stephanie F. James 1 email, Ravi Mahalingam 1 email and Don Gilden 1,2,* email
1 Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA 2 Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
* Author to whom correspondence should be addressed.
Received: 13 August 2012; in revised form: 5 September 2012 / Accepted: 6 September 2012 / Published: 11 September 2012
(This article belongs to the Special Issue Modulation of Apoptosis by Viral Infection)
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Abstract: Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV.
Keywords: varicella zoster virus; apoptosis

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Cite This Article

MDPI and ACS Style

James, S.F.; Mahalingam, R.; Gilden, D. Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? Viruses 2012, 4, 1509-1514.

AMA Style

James SF, Mahalingam R, Gilden D. Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? Viruses. 2012; 4(9):1509-1514.

Chicago/Turabian Style

James, Stephanie F.; Mahalingam, Ravi; Gilden, Don. 2012. "Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?" Viruses 4, no. 9: 1509-1514.

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