Next Article in Journal / Special Issue
Changes in Population Dynamics in Mutualistic versus Pathogenic Viruses
Previous Article in Journal
Cidofovir Activity against Poxvirus Infections
Previous Article in Special Issue
Exploratory Spatial Analysis of in vitro Respiratory Syncytial Virus Co-infections
Article Menu

Article Versions

Export Article

Open AccessReview
Viruses 2011, 3(1), 1-11; doi:10.3390/v3010001

Rev Variation during Persistent Lentivirus Infection

1
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
2
Department of Statistics, Iowa State University, Ames, IA 50011, USA
3
Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011, USA
*
Author to whom correspondence should be addressed.
Received: 20 November 2010 / Revised: 29 December 2010 / Accepted: 6 January 2011 / Published: 11 January 2011
(This article belongs to the Special Issue Virus Dynamics and Evolution)
Download PDF [397 KB, uploaded 12 May 2015]

Abstract

The ability of lentiviruses to continually evolve and escape immune control is the central impediment in developing an effective vaccine for HIV-1 and other lentiviruses. Equine infectious anemia virus (EIAV) is considered a useful model for immune control of lentivirus infection. Virus-specific cytotoxic T lymphocytes (CTL) and broadly neutralizing antibody effectively control EIAV replication during inapparent stages of disease, but after years of low-level replication, the virus is still able to produce evasion genotypes that lead to late re-emergence of disease. There is a high rate of genetic variation in the EIAV surface envelope glycoprotein (SU) and in the region of the transmembrane protein (TM) overlapped by the major exon of Rev. This review examines genetic and phenotypic variation in Rev during EIAV disease and a possible role for Rev in immune evasion and virus persistence.
Keywords: lentivirus; Rev; equine infectious anemia virus; selection; immune evasion; overlapping reading frames lentivirus; Rev; equine infectious anemia virus; selection; immune evasion; overlapping reading frames
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Carpenter, S.; Chen, W.-C.; Dorman, K.S. Rev Variation during Persistent Lentivirus Infection. Viruses 2011, 3, 1-11.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top