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Viruses 2010, 2(11), 2536-2540; doi:10.3390/v2112536
Commentary

Mind the Gap: How Some Viruses Infect Their Hosts

Jr.
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Received: 19 October 2010 / Revised: 10 November 2010 / Accepted: 11 November 2010 / Published: 12 November 2010
(This article belongs to the Section Editorial)
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Abstract

Cryo-electron microscopy (Cryo-EM) and cryo-electron tomography (Cryo-ET) provide structural insights into complex biological processes. The podoviridae are dsDNA containing phage with short, non-contractile tails which nevertheless translocate their DNA into the cytoplasm of their host cells. Liu et al. [1] used a combination of cryo-EM and cryo-ET to study the structural changes accompanying infection of P. marinus by the phage P-SSP7 and thereby provide unique molecular insight into the process by which the DNA transits from phage to host during infection.
Keywords: Cyanophage P-SSP7 phage; DNA injection; cryo-electron microscopy; cryo-electron tomography Cyanophage P-SSP7 phage; DNA injection; cryo-electron microscopy; cryo-electron tomography
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Prevelige, P.E., Jr. Mind the Gap: How Some Viruses Infect Their Hosts. Viruses 2010, 2, 2536-2540.

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