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Viruses 2010, 2(11), 2536-2540; doi:10.3390/v2112536
Commentary

Mind the Gap: How Some Viruses Infect Their Hosts

Jr.
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Received: 19 October 2010 / Revised: 10 November 2010 / Accepted: 11 November 2010 / Published: 12 November 2010
(This article belongs to the Section Editorial)
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Abstract

Cryo-electron microscopy (Cryo-EM) and cryo-electron tomography (Cryo-ET) provide structural insights into complex biological processes. The podoviridae are dsDNA containing phage with short, non-contractile tails which nevertheless translocate their DNA into the cytoplasm of their host cells. Liu et al. [1] used a combination of cryo-EM and cryo-ET to study the structural changes accompanying infection of P. marinus by the phage P-SSP7 and thereby provide unique molecular insight into the process by which the DNA transits from phage to host during infection.
Keywords: Cyanophage P-SSP7 phage; DNA injection; cryo-electron microscopy; cryo-electron tomography Cyanophage P-SSP7 phage; DNA injection; cryo-electron microscopy; cryo-electron tomography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prevelige, P.E., Jr. Mind the Gap: How Some Viruses Infect Their Hosts. Viruses 2010, 2, 2536-2540.

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