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Viruses 2010, 2(11), 2436-2442; doi:10.3390/v2112436
Commentary

Making of Viral Replication Organelles by Remodeling Interior Membranes

 and
*
Department of Plant Pathology, University of Kentucky, 201F Plant Science Building, Lexington, KY 40546, USA
* Author to whom correspondence should be addressed.
Received: 8 October 2010 / Revised: 29 October 2010 / Accepted: 1 November 2010 / Published: 5 November 2010
(This article belongs to the Section Editorial)
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Abstract

Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory [1] gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.
Keywords: virus replication; membrane remodeling; host factor; poliovirus; Arf1 virus replication; membrane remodeling; host factor; poliovirus; Arf1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Sasvari, Z.; Nagy, P.D. Making of Viral Replication Organelles by Remodeling Interior Membranes. Viruses 2010, 2, 2436-2442.

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