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Viruses 2010, 2(11), 2404-2408; doi:10.3390/v2112404

Detecting Retroviral Sequences in Chronic Fatigue Syndrome

Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
Received: 26 October 2010 / Revised: 2 November 2010 / Accepted: 2 November 2010 / Published: 3 November 2010
(This article belongs to the Section Editorial)
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XMRV or xenotropic murine leukemia virus-related retrovirus, a recently discovered retrovirus, has been linked to both prostate cancer and chronic fatigue syndrome (CFS). Recently, the teams of Drs. Shyh-Ching Lo and Harvey Alter discovered the presence of sequences closely related to XMRV in the blood of 86.5% of patients with CFS [1]. These findings are important because since the initial discovery of XMRV in CFS, several studies have failed to find XMRV in specimens collected from CFS patients. While the current study also did not find XMRV in CFS, Lo et al. did detect sequences that belong to polytropic mouse endogenous retroviruses (PMV), which share considerable similarity with XMRV. Criteria for future studies that will help bring greater clarity to the issue of retroviral sequences in CFS are proposed below.
Keywords: polytropic and modified polytropic viruses; XMRV; PMV; M-PMV polytropic and modified polytropic viruses; XMRV; PMV; M-PMV
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Singh, I.R. Detecting Retroviral Sequences in Chronic Fatigue Syndrome. Viruses 2010, 2, 2404-2408.

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