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Viruses 2010, 2(1), 314-333; doi:10.3390/v2010314

Herpesviruses and Autophagy: Catch Me If You Can!

INSERM U756 and Université Paris-Sud 11, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément 92290 Châtenay-Malabry, France
* Author to whom correspondence should be addressed.
Received: 18 November 2009 / Revised: 19 January 2010 / Accepted: 22 January 2010 / Published: 26 January 2010
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
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Autophagy is an evolutionarily conserved cellular degradation pathway involving the digestion of intracellular components via the lysosomal pathway. The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles and proteins, but it is also stimulated by environmental stress conditions, such as starvation, oxidative stress, and the accumulation of misfolded proteins. It also acts as a cellular defense mechanism against microorganisms by contributing to both the innate and adaptive immunity, and by eliminating intracellular pathogens (xenophagy). There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. However, it is well-known that Herpesviruses are smart pathogens and several, such as HSV-1, HCMV and HHV-8, are known to have developed numerous defense strategies for evading the host’s immune response. Inhibition of the antiviral autophagic mechanism has also been reported. Autophagy has also been shown to enhance the major histocompatibility complex presentation of at least two viral proteins, the EBVencoded EBNA-1 and the HSV-1 encoded gB. In this review, we present an overview of recent advances in our understanding of the complex interplay between autophagy and Herpesviruses.
Keywords: autophagy; Herpesvirus; HSV-1; cytomegalovirus; HHV-8; immunity; autophagosome autophagy; Herpesvirus; HSV-1; cytomegalovirus; HHV-8; immunity; autophagosome
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cavignac, Y.; Esclatine, A. Herpesviruses and Autophagy: Catch Me If You Can! Viruses 2010, 2, 314-333.

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