The Virology of Taterapox Virus In Vitro
AbstractTaterapox virus (TATV) is phylogenetically the closest related virus to variola—the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus. In vivo, TATV can infect several animals but produces an inapparent infection in wild-type mice; however, TATV does cause morbidity and mortality in some immunocompromised strains. We employed in vitro techniques to compare TATV to ectromelia (ECTV) and vaccinia (VACV) viruses. Both ECTV and TATV replicate efficiently in primate cell lines but TATV replicates poorly in murine cells lines. Furthermore, TATV induces cytopathic effects, but to a lesser extent than ECTV, and changes cytoskeletal networks differently than both ECTV and VACV. Bioinformatic studies revealed differences in several immunomodulator open reading frames that could contribute to the reduced virulence of TATV, which were supported by in vitro cytokine assays. View Full-Text
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Parker, S.; Camilo de Oliveira, L.; Lefkowitz, E.J.; Hendrickson, R.C.; Bonjardim, C.A.; Wold, W.S.M.; Hartzler, H.; Crump, R.; Buller, R.M. The Virology of Taterapox Virus In Vitro. Viruses 2018, 10, 463.
Parker S, Camilo de Oliveira L, Lefkowitz EJ, Hendrickson RC, Bonjardim CA, Wold WSM, Hartzler H, Crump R, Buller RM. The Virology of Taterapox Virus In Vitro. Viruses. 2018; 10(9):463.Chicago/Turabian Style
Parker, Scott; Camilo de Oliveira, Leonardo; Lefkowitz, Elliot J.; Hendrickson, Robert C.; Bonjardim, Cláudio A.; Wold, William S.M.; Hartzler, Hollyce; Crump, Ryan; Buller, Robert M. 2018. "The Virology of Taterapox Virus In Vitro." Viruses 10, no. 9: 463.
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