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Viruses 2018, 10(8), 420; https://doi.org/10.3390/v10080420

Influenza Virus Infection of Human Lymphocytes Occurs in the Immune Cell Cluster of the Developing Antiviral Response

1
Department of Medicine, School of Medicine, University of Rochester, Rochester, NY 14642, USA
2
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
3
Division of Infectious Diseases and Immunology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
*
Author to whom correspondence should be addressed.
Received: 16 July 2018 / Revised: 7 August 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue What’s New with Flu?)
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Abstract

Monocytes-macrophages and lymphocytes are recruited to the respiratory tract in response to influenza virus challenge and are exposed to the virus during the establishment of immune defenses. The susceptibility of human lymphocytes to infection was assessed. The presence of monocytes-macrophages was required to attain infection of both resting and proliferating lymphocytes. Lymphocyte infection occurred in the context of immune cell clusters and was blocked by the addition of anti-intercellular adhesion molecule-1 (ICAM-1) antibody to prevent cell clustering. Both peripheral blood-derived and bronchoalveolar lymphocytes were susceptible to infection. Both CD4+ and CD8+ T lymphocytes were susceptible to influenza virus infection, and the infected CD4+ and CD8+ lymphocytes served as infectious foci for other nonpermissive or even virus-permissive cells. These data show that monocytes-macrophages and both CD4+ and CD8+ lymphocytes can become infected during the course of an immune response to influenza virus challenge. The described leukocyte interactions during infection may play an important role in the development of effective anti-influenza responses. View Full-Text
Keywords: influenza virus; human monocytes; human macrophages; human lymphocytes; immune cell clusters; alveolar lymphocytes influenza virus; human monocytes; human macrophages; human lymphocytes; immune cell clusters; alveolar lymphocytes
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Mock, D.J.; Frampton, M.W.; Nichols, J.E.; Domurat, F.M.; Signs, D.J.; Roberts, N.J., Jr. Influenza Virus Infection of Human Lymphocytes Occurs in the Immune Cell Cluster of the Developing Antiviral Response. Viruses 2018, 10, 420.

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