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Algorithms 2015, 8(4), 1088-1110; doi:10.3390/a8041088

Computer Aided Diagnosis System for Early Lung Cancer Detection

Department of Electrical and Computer Engineering, Khalifa University, Abu Dhabi, AD 127788, U.A.E
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Academic Editor: Kenji Suzuki
Received: 2 June 2015 / Accepted: 10 November 2015 / Published: 20 November 2015
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Abstract

Lung cancer continues to rank as the leading cause of cancer deaths worldwide. One of the most promising techniques for early detection of cancerous cells relies on sputum cell analysis. This was the motivation behind the design and the development of a new computer aided diagnosis (CAD) system for early detection of lung cancer based on the analysis of sputum color images. The proposed CAD system encompasses four main processing steps. First is the preprocessing step which utilizes a Bayesian classification method using histogram analysis. Then, in the second step, mean shift segmentation is applied to segment the nuclei from the cytoplasm. The third step is the feature analysis. In this step, geometric and chromatic features are extracted from the nucleus region. These features are used in the diagnostic process of the sputum images. Finally, the diagnosis is completed using an artificial neural network and support vector machine (SVM) for classifying the cells into benign or malignant. The performance of the system was analyzed based on different criteria such as sensitivity, specificity and accuracy. The evaluation was carried out using Receiver Operating Characteristic (ROC) curve. The experimental results demonstrate the efficiency of the SVM classifier over other classifiers, with 97% sensitivity and accuracy as well as a significant reduction in the number of false positive and false negative rates. View Full-Text
Keywords: compute-aided diagnosis; sputum images; lung cancer detection; Bayesian theorem; mean shift segmentation; feature extraction; neural network; support vector machine compute-aided diagnosis; sputum images; lung cancer detection; Bayesian theorem; mean shift segmentation; feature extraction; neural network; support vector machine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Taher, F.; Werghi, N.; Al-Ahmad, H. Computer Aided Diagnosis System for Early Lung Cancer Detection. Algorithms 2015, 8, 1088-1110.

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