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Materials 2016, 9(5), 384; doi:10.3390/ma9050384

Fabrication of a Delaying Biodegradable Magnesium Alloy-Based Esophageal Stent via Coating Elastic Polymer

1,†
,
2,†
,
3
,
4
,
1,* , 1,* and 2,*
1
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, 600 Yi Shan Road, Shanghai 200233, China
2
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou 215006, China
3
Department of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai 200237, China
4
Zhejiang Zylox Medical Device Co., Ltd., No. 1500, Wenyi West Road, Hangzhou 311121, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Fabio Nudelman
Received: 4 March 2016 / Revised: 18 April 2016 / Accepted: 11 May 2016 / Published: 17 May 2016
(This article belongs to the Special Issue Biological and Synthetic Organic–Inorganic Composite Materials)
View Full-Text   |   Download PDF [4133 KB, uploaded 17 May 2016]   |  

Abstract

Esophageal stent implantation can relieve esophageal stenosis and obstructions in benign esophageal strictures, and magnesium alloy stents are a good candidate because of biodegradation and biological safety. However, biodegradable esophageal stents show a poor corrosion resistance and a quick loss of mechanical support in vivo. In this study, we chose the elastic and biodegradable mixed polymer of Poly(ε-caprolactone) (PCL) and poly(trimethylene carbonate) (PTMC) as the coated membrane on magnesium alloy stents for fabricating a fully biodegradable esophageal stent, which showed an ability to delay the degradation time and maintain mechanical performance in the long term. After 48 repeated compressions, the mechanical testing demonstrated that the PCL-PTMC-coated magnesium stents possess good flexibility and elasticity, and could provide enough support against lesion compression when used in vivo. According to the in vitro degradation evaluation, the PCL-PTMC membrane coated on magnesium was a good material combination for biodegradable stents. During the in vivo evaluation, the proliferation of the smooth muscle cells showed no signs of cell toxicity. Histological examination revealed the inflammation scores at four weeks in the magnesium-(PCL-PTMC) stent group were similar to those in the control group (p > 0.05). The α-smooth muscle actin layer in the media was thinner in the magnesium-(PCL-PTMC) stent group than in the control group (p < 0.05). Both the epithelial and smooth muscle cell layers were significantly thinner in the magnesium-(PCL-PTMC) stent group than in the control group. The stent insertion was feasible and provided reliable support for at least four weeks, without causing severe injury or collagen deposition. Thus, this stent provides a new stent for the treatment of benign esophageal stricture and a novel research path in the development of temporary stents in other cases of benign stricture. View Full-Text
Keywords: benign esophageal stricture; biodegradable stent; magnesium; PCL-PTMC membrane benign esophageal stricture; biodegradable stent; magnesium; PCL-PTMC membrane
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Yuan, T.; Yu, J.; Cao, J.; Gao, F.; Zhu, Y.; Cheng, Y.; Cui, W. Fabrication of a Delaying Biodegradable Magnesium Alloy-Based Esophageal Stent via Coating Elastic Polymer. Materials 2016, 9, 384.

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